aspg-3-3574-1791417687 20261008000127 American Scientific Publishing Group admin@americaspg.com American Scientific Publishing Group Fusion: Practice and Applications FPA 2770-0070 2692-4048 2025 19 1 Hemalatha Dendukuri Department of CSE, SRKR Engineering College (A), Bhimavaram, A.P, India Kachapuram Basava Raju Department of AI, Anurag University, Hyderabad, India S. Phani Praveen Department of CSE, PVP Siddhartha Institute of Technology, Vijayawada, A.P, India Janjhyam V. Naga Ramesh Department of CSE, Graphic Era Hill University, Dehradun, 248002, India; Department of CSE, Graphic Era Deemed To Be University, Dehradun, 248002, Uttarakhand, India Vahiduddin Shariff Department of CSE, Sir C R Reddy College of Engineering, Eluru, A.P, India N. S. Koti Mani Kumar Tirumanadham Department of CSE, Sir C R Reddy College of Engineering, Eluru, A.P, India This study proposes the novel machine learning concepts to enhance both prediction accuracy of diabetes detection and interpretation of diagnostic models. First, the methodology uses multiple imputations by chained equations (MICE) to complete data before analysis through missing data imputation procedures. The class imbalance problem is solved through the implementation of Synthetic Minority Over-sampling Technique (SMOTE). The Interquartile Range (IQR) outlier detection method helps remove outliers because it enhances model robustness. The hybrid RFE-WWO selection process combines Recursive Feature Elimination (RFE) with Water Wave optimization (WWO) to select important features that strike the right balance between model complexity and prediction accuracy. The HFM framework contains the Hybrid Fusion Model as its essential component, which merges AdaBoost's and CatBoost's most favorable aspects. The hyperparameter optimization with TPE leads to model tuning which reaches a prediction accuracy of 97.84% through the application of Tree-Structured Parzen Estimator. The entire approach delivers enhanced accuracy and it improves precision along with recall metrics and F1 score performance of the predictive model. The framework shows significant potential for early diagnosis by merging these advanced techniques since ensemble methods are essential for healthcare data analysis while accurate interpretable models are vital to create dependable diagnostic tools. 2025 57 74 3574 https://creativecommons.org/licenses/by/4.0/ 10.54216/FPA.190106 https://www.americaspg.com/journal/3/article/3574 https://www.americaspg.com/storage/71739578392.pdf