aspg-31-4407-1791686792 20261011024632 American Scientific Publishing Group admin@americaspg.com American Scientific Publishing Group International Journal of Advances in Applied Computational Intelligence IJAACI 2833-5600 2026 8 1 Sukkirtha K. Ramanujan Computing Centre, Anna University, Chennai, Tamil Nadu, India Anbuchelian S. Ramanujan Computing Centre, Anna University, Chennai, Tamil Nadu, India John A. Ramanujan Computing Centre, Anna University, Chennai, Tamil Nadu, India The advancement of trustworthy diagnostic tools in dermatological automation is hindered by the limited transparency of current deep learning systems, which function as opaque models and impede clinical acceptance. This research presents a novel intelligent framework for skin lesion analysis that unites deep learning methodologies with explainable artificial intelligence (XAI) principles to address this interpretability deficit. The proposed approach utilizes a transfer-learned ResNet50 architecture for robust image classification, coupled with Local Interpretable Model-agnostic Explanations (LIME) to furnish clear, visual justifications for the model’s outputs. Performance assessment on the HAM10000 benchmark yielded a classification accuracy of 94.3%, with a validation accuracy of 91.8%. Concurrently, the LIME framework effectively identified and visualized diagnostically critical features in the lesion images, thereby elucidating the model’s reasoning process for medical practitioners. These findings confirm that augmenting high-performance deep learning with post-hoc explanatory techniques yields a credible and understandable diagnostic instrument, thereby promoting clinician trust and facilitating data-informed medical judgments. Subsequent developments will prioritize scalable cloud implementation, interoperability with healthcare information systems, extension to underrepresented lesion categories, and rigorous evaluation in diverse clinical environments. 2026 05 12 4407 https://creativecommons.org/licenses/by/4.0/ 10.54216/IJAACI.080102 https://www.americaspg.com/journal/31/article/4407 https://www.americaspg.com/storage/articles/manuscripts/01M332Y7S060FNCPGSMER8C7HW.pdf