Journal of Intelligent Systems and Internet of Things JISIoT 2690-6791 2769-786X 10.54216/JISIoT https://www.americaspg.com/journals/show/1236 2019 2019 Nova Information Management School, Universidade Nova de Lisboa, 1070-312, Lisboa, Portugal Ahmed Abdelaziz Nova Information Management School, Universidade Nova de Lisboa, 1070-312, Lisboa, Portugal Alia N. Mahmoud Futuristic sustainable computing solutions in e-healthcare applications were depends on the Internet of Things (IoT) and cloud computing (CC), has provided several features and realistic services. IoT-related medical devices gather the necessary data like recurrent transmissions in health limitations and upgrade the exactness of health limitations all inside a standard period. These data can be generated from different types of sensors in different formats. As a result, the data fusion is a big challenge to handle these IoT-based data. Moreover, IoT gadgets and medical parameters based on sensor readings are deployed for detecting diseases at the correct time beforehand attaining the rigorous state. Machine learning (ML) methods play a very significant task in determining decisions and managing a large volume of data. This manuscript offers a new Hyperparameter Tuned Deep learning Enabled Clustered IoT Based Smart Healthcare System (HPTDLEC-SHS) model. The presented HPTDLEC-SHS technique mainly focuses on the clustering of IoT devices using weighted clustering scheme and enables disease diagnosis process. At the beginning level, the HPTDLEC-SHS technique exploits min-max data normalization technique to convert the input data into compatible format. Besides, the gated recurrent unit (GRU) model is utilized to carry out the classification process. Finally, Jaya optimization algorithm (JOA) is exploited to fine tune the hyperparameters related to the GRU model. To demonstrate the enhanced performance of the HPTDLEC-SHS technique, an extensive comparative outcome highlighted its supremacy over other models. 2022 2022 22 31 10.54216/JISIoT.060202 https://www.americaspg.com/articleinfo/18/show/1236