Journal of Intelligent Systems and Internet of Things JISIoT 2690-6791 2769-786X 10.54216/JISIoT https://www.americaspg.com/journals/show/4104 2019 2019 Electronics and Communications Engineering Department, Faculty of Engineering, Delta University for Science and Technology, Gamasa City 11152, Egyp Mohamed Mohamed College of Engineering, University of Bahrain, Bahrain Ebrahim A. Mattar Faculty of Artificial Intelligence, Delta University for Science and Technology, Mansoura 11152, Egypt; Jadara Research Center, Jadara University, Irbid 21110, Jordan Marwa M. Eid Delta Higher Institute of Engineering and Technology, Department for Communications and Electronics, Mansoura 35511, Egypt; Applied Science Research Center. Applied Science Private University, Amman, Jordan El-Sayed M. El El-kenawy Chronic Kidney Disease (CKD) is a global health concern that necessitates accurate and timely detection to improve patient outcomes and reduce healthcare costs. This study focuses on enhancing CKD classification using machine learning techniques, leveraging 400 instances with 25 clinical features to predict binary outcomes of CKD or non-CKD. The main objective is to improve detection accuracy by applying feature selection and model optimization. Standard machine learning models, including Multilayer Perceptron (MLP), Random Forest (RF), Support Vector Classifier (SVC), and K-Nearest Neighbors (KNN), were employed, with optimization achieved through binary optimization algorithms such as Greylag Goose Optimization (GGO), Particle Swarm Optimization (PSO), Bat Algorithm (BA), and Whale Optimization Algorithm (WAO), along with hyperparameter tuning using genetic algorithms and other metaheuristics. Results indicate significant improvements in classification performance after feature selection and optimization, with the GGO-optimized MLP model achieving an accuracy of 97.06%. The contributions of this paper include (i) benchmarking baseline models for CKD detection, (ii) a comprehensive analysis of feature selection strategies, (iii) optimization of machine learning models for CKD classification, and (iv) visualization of model performance to aid future research in healthcare machine learning applications. 2025 2025 152 190 10.54216/JISIoT.170211 https://www.americaspg.com/articleinfo/18/show/4104